Advanced in-vitro solutions including ciPTEC renal cell lines, assay-ready cells and vesicle kits for drug transport and pharmaceutical research-
In-Vitro Cell Models & Vesicle Kits;
Vesicle Kits & ciPTEC Cell Lines for In-Vitro Research
The range includes human ciPTEC renal proximal tubule cell models, assay-ready cells, licensed proliferative cell lines and HEK293-derived membrane vesicle kits for ABC transporter studies.
ciPTEC Human Renal Cell Lines
ciPTEC is a conditionally immortalised human proximal tubule epithelial cell model designed to reproduce important functional characteristics of human renal proximal tubule cells. The platform maintains relevant proximal tubular markers and drug-transporter functionality and can be used for studies involving renal drug transport, drug interactions and nephrotoxicity.
ciPTEC-parental License
Human renal proximal tubule epithelial cell line supplied under license with proliferative capacity for academic or commercial research.
The parental ciPTEC model reproduces key characteristics of proximal tubular epithelial cells and maintains relevant renal transport functions and markers. It provides a robust in-vitro platform for renal physiology, drug transport and toxicity research.
Category: ciPTEC Licenses - Storage: -80 °C ; Shipment: Dry ice
ciPTEC-OAT1 License
Human ciPTEC renal cell line incorporating functional Organic Anion Transporter 1 (OAT1).
The model is based on the ciPTEC platform and provides functional uptake through OAT1, making it suitable for renal drug-transporter studies, pharmacokinetic research, drug-drug interaction assessment and nephrotoxicity investigations.
Category: ciPTEC Licenses; Storage: -80 °C; Shipment: Dry ice
ciPTEC-OAT3 License
Human ciPTEC renal cell line incorporating functional Organic Anion Transporter 3 (OAT3).
Based on the ciPTEC platform, the model provides functional organic anion uptake via OAT3 and is designed for studies of renal drug transport, drug interactions, pharmacokinetics and renal toxicity.
Category: ciPTEC Licenses; Storage: -80 °C; Shipment: Dry ice
Bundle of ciPTEC (Parental, OAT1 and OAT3) – 1 License
Catalog No.: C4PCELL004
Combined license providing access to three ciPTEC renal cell models: parental ciPTEC, ciPTEC-OAT1 and ciPTEC-OAT3.
The bundle provides a broader in-vitro platform for studying renal drug transport and toxicity, including functional organic anion transport through OAT1 and OAT3.
Storage: -80 °C
Shipment: Dry ice
Use: Academic or commercial
ciPTEC Assay Ready Cells
Assay-ready ciPTEC products are supplied as pre-differentiated, ready-to-use renal proximal tubule cells, reducing cell preparation time before experimental use.
ciPTEC-parental Assay Ready Cells
Pre-differentiated, ready-to-use parental ciPTEC cells for in-vitro renal research.
The model reproduces important characteristics of human proximal tubule epithelial cells and can be used for drug transport, toxicity and renal physiology studies without the need for extensive cell expansion and differentiation before use.
Category: ciPTEC Assay Ready Cells
Storage: -80 °C
Shipment: Dry ice
ciPTEC-OAT1 Assay Ready Cells
SKU: C4PARC002
Pre-differentiated, ready-to-use human ciPTEC renal cells with functional Organic Anion Transporter 1 (OAT1) activity.
The cells are based on the parental ciPTEC model and support functional uptake through OAT1. They retain key proximal tubular characteristics and transport functionality, making them suitable for renal drug transport, drug-drug interaction and nephrotoxicity studies.
Storage: -80 °C
Shipment: Dry ice
Shipment methods: World Courier
ciPTEC-OAT3 Assay Ready Cells
Catalog No.: C4PARC003
Pre-differentiated, ready-to-use ciPTEC renal cells providing functional uptake through Organic Anion Transporter 3 (OAT3).
The cells retain important proximal tubular markers and transporter functions and provide an in-vitro platform for renal transporter, pharmacokinetic and toxicity studies.
Storage: -80 °C
Shipment: Dry ice
Shipment methods: World Courier
Vesicle Kits
The vesicle kits use inside-out membrane vesicles derived from HEK293 cells expressing human ABC efflux transporters. Substrate transport into the vesicles is ATP-dependent and can be measured using fluorescence, radiolabel or LC-MS detection.
The kits are designed for applications such as substrate identification, inhibition studies, kinetic analysis and drug-drug interaction research. Standard vesicle kits provide materials for approximately 100 reactions, including membrane vesicles, ATP, AMP, assay buffer and stop/wash buffer.
Human Pgp Vesicle Kit (HEK293 Derived)
Catalog No.: C4PVK010
HEK293-derived inside-out membrane vesicles expressing human P-glycoprotein / MDR1 / ABCB1.
Designed for vesicular transport assays involving Pgp substrates and inhibitors. Suitable for substrate determination, inhibition studies and transporter kinetic experiments.
Transporter: Pgp / MDR1 / ABCB1
Protein concentration: 1.5 mg/mL
Volume: 4 × 500 µL
Number of assays: 100
Transport ratio ATP/AMP: >5
Storage: -80 °C
Shelf life: 2 years from shipment
Human MRP1 Vesicle Kit (HEK293 Derived)
HEK293-derived inside-out membrane vesicles expressing human MRP1 / ABCC1.
Developed for ATP-dependent transport studies involving multidrug resistance-associated protein 1. Suitable for transporter substrate identification, inhibition and drug interaction studies.
Transporter: MRP1 / ABCC1
Typical transport ratio ATP/AMP: >5
Human MRP2 Vesicle Kit (HEK293 Derived)
HEK293-derived membrane vesicles expressing human MRP2 / ABCC2, an ATP-dependent efflux transporter involved in transport of organic anions and conjugated compounds.
Suitable for substrate transport, inhibition, kinetics and drug-drug interaction studies.
Transporter: MRP2 / ABCC2
Typical transport ratio ATP/AMP: >20
Human MRP3 Vesicle Kit (HEK293 Derived)
HEK293-derived inside-out membrane vesicles expressing human MRP3 / ABCC3.
Suitable for ATP-dependent transporter studies including substrate screening, inhibitor evaluation and kinetic characterization.
Transporter: MRP3 / ABCC3
Typical transport ratio ATP/AMP: >10
Human MRP4 Vesicle Kit (HEK293 Derived)
Catalog No.: C4PVK004
HEK293-derived membrane vesicles expressing human MRP4 / ABCC4 for vesicular transport assays.
Designed for substrate determination, inhibition studies and transporter kinetic analysis.
Protein concentration: 1.5 mg/mL
Volume: 4 × 500 µL
Number of assays: 100
Reference substrate: DHEAS
Transport ratio ATP/AMP: >5
Storage: -80 °C
Shelf life: 2 years from shipment
Human MRP5 Vesicle Kit (HEK293 Derived)
HEK293-derived inside-out membrane vesicles expressing human MRP5 / ABCC5.
Suitable for ATP-dependent transport, substrate screening, inhibition and interaction studies involving the MRP5 transporter.
Transporter: MRP5 / ABCC5
Typical transport ratio ATP/AMP: >3
Human MRP8 Vesicle Kit (HEK293 Derived)
HEK293-derived inside-out membrane vesicles expressing human MRP8 / ABCC11.
Designed for ATP-dependent vesicular transport studies involving MRP8 substrates, including transporter characterization and inhibitor screening.
Transporter: MRP8 / ABCC11
Typical transport ratio ATP/AMP: >3
Human BCRP Vesicle Kit (HEK293 Derived)
HEK293-derived inside-out membrane vesicles expressing human Breast Cancer Resistance Protein (BCRP / ABCG2).
Suitable for substrate transport, inhibition and drug-drug interaction studies involving this major ABC efflux transporter.
Transporter: BCRP / ABCG2
Typical transport ratio ATP/AMP: >10
Human BSEP Vesicle Kit (HEK293 Derived)
HEK293-derived inside-out membrane vesicles expressing human Bile Salt Export Pump (BSEP / ABCB11).
Designed for ATP-dependent BSEP transport studies and particularly relevant for investigation of bile acid transport and potential transporter-mediated cholestatic effects.
Protein concentration: 1.5 mg/mL
Number of assays: 100
Reference substrate: Taurocholate / TCA
Transport ratio ATP/AMP: >10
Storage: -80 °C
Shelf life: 2 years from shipment
Human Control Vesicle Kit (HEK293 Derived)
Control HEK293-derived membrane vesicles designed to serve as a reference for vesicular transport assays.
The control kit can be used alongside transporter-expressing vesicles to distinguish transporter-specific ATP-dependent uptake from background or non-specific transport effects.
FluoPgp
Catalog No.: C4PVK011
FluoPgp is a fluorescent substrate developed specifically for P-glycoprotein (Pgp) transport studies.
It can be used in both cell-based and vesicular transport assays and provides a fluorescence-based alternative to radiolabel or LC-MS detection methods for Pgp experiments.
Form: Solution
Concentration: 2 mM
Solvent: Water
Volume: 100 µL
Storage: -20 °C
Shelf life: 2 years from shipment
Approximate capacity: 3,000 reactions
