High performance free from vibrations in manual operation

Drift and electromagnetic disturbance are critical problems in patch clamping work. This mechanical micromanipulator was developed specifically for patch clamping: it does not employ a liquid hydraulic system (which is prone to drift caused by temperature changes), has no spring (a common cause of mechanical drifting), nor a motor (which is a source of noise). Its body is designed to absorb vibrations, so that even at high magnifications, problems of vibrations are virtually non-existent. Based on a drum type design, which is highly reputed as a liquid hydraulic method, and with a very stable center of gravity, this model provides exceptionally steady and stable performance. The overall design is compact, so installation requires a minimum of space. With coarse and fine manipulators integrated in the compact body, this model handles a full range of required movements, from moving a microelectrode into the microscope view field to making contact with the cell

* To install the manipulator on the microscope, a mounting adapter suitable for the microscope is required separately

* Alternatively, the manipulator can be mounted directly on the isolation table

* The patch clamp headstage holder AP-13-3 can be attached to the solid universal joint UST-2 included in the manipulator

* The One-Axis Water Hydraulic Micromanipulator MHW-4 / MHW-4-1 (sold separately) can be attached with the manipulator attachment P-11 (sold separately), allowing for the addition of a diagonal axis to the XYZ axes

Joint

An accessory for the NMN-21, also available separately. Loosening the knob allows the electrode to rotate freely in two dimensions, and tightening it fixes the angle, making adjustments intuitive and easy

UST-2 Solid Universal Joint

Setting example

Mounting adaptor setting example	ITS + NR-12 + NMN-21 setting example

* The manipulator can be installed on the isolation table with a third-party magnetic base using mounting plate GJ-12A (sold separately)

	Please use a magnetic base that meets the following specifications: the mounting plate GJ-12A (sold separately)
Set-up of the NMN-21, GJ-12A, magnetic base, and ITS2	Accessories included in GJ-12A Mounting screw (M4×8): 4 pieces (for the magnet installation) Mounting screw (Low head M6×8): 2 pieces. Hex wrench (width across flats: 3 mm): 1 piece

By connecting the separately sold P-11 to the included UST-2 unit, the one-axis water hydraulic micromanipulator MHW-4-1 (precision: 1 µm, 250 µm per rotation) can be attached. This allows vibration-free fine-drive control at the same angle as the electrode, and by rotating the control knob located away from the drive unit, it can be easily operated with fingertips

Set-up image of MHW-4-1, P-11, and NMN-21

Specification

System Diagram